This product is known as the anti-aging "magic medicine" of benefiting the people. In July 2019, McLane, a wholly-owned subsidiary of Warren Buffett, announced that it had reached a strategic cooperation with herbalmax of the United States, taking this opportunity to officially enter the field of biotechnology. It was the "anti-aging factor" β - nicotinamide mononucleotide (NMN), which was a revolutionary breakthrough in the biological field, was the first to launch the mature oral product revido (Jingdong official flagship store price: 1980 yuan / bottle) Research and development institutions. This time, the cooperation between Warren Buffett's McLane company and herbalmax, a R & D institution of revido, may put an end to all kinds of confusion in the market for NAD + precursor NMN aging inhibitors. The basic version of revido launched by herbalmax later sold for less than 2000 yuan (the price of Jingdong platform was 1980 yuan). It successfully introduced NAD + precursor NMN, a cutting-edge biotechnology, into ordinary high-level consumers. NMN is actually a precursor of NAD +, which was discovered by David Sinclair, Professor of genetics at Harvard Medical School in 2013. During the experiment, David Sinclair divided the experimental mice into two groups: one group ate NMN, the other group did not eat NMN. After a period of observation, it was found that the aging signs of tissues and muscles in the mice fed with NMN were reversed, while the mice without NMN entered the aging state normally. Chinese people have never been stingy about the consumption of nutrition and health care products. According to the data report in 2018, China's sales revenue of nutrition and health care products in this year reached 289.8 billion yuan, with a year-on-year growth rate of 18.52%. The data for 2019 have not yet come out, and the overall scale is expected to be quite large. As we all know, Philippine people are willing to spend more money on health care products, and the more expensive the health care products are, the more expensive they are willing to buy health care products. NMN (β - nicotinamide mononucleotide), an anti-aging drug that has only become popular in the middle class in the last two years. 1、 The first dawn -- related research and experiment of NMN The research in the field of anti-aging has made unprecedented development in the 21st century. At present, a variety of aging mechanisms have been found, among which the study of mitochondrial DNA damage to cell senescence mechanism is one of the hot spots at home and abroad. Mitochondria are the main site of energy metabolism. The energy materials needed by cell activities are mainly produced in mitochondria. With the increase of age, the activity of mitochondria decreases, which accelerates the senescence of mitochondria, cells and even the whole body, and gradually enters a vicious circle. In 2015, Professor Junichiro Imai of the University of Washington found that long-term administration of nicotinamide mononucleotide (NMN) can reduce the physiological decline related to age in mice and alleviate some typical aging symptoms. Studies have shown that NMN can be quickly absorbed by the stomach and intestines and spread throughout the body, reaching the capillary within 15 minutes, which can improve mitochondrial function and energy metabolism. NMN supplementation has a lot of beneficial effects on the body, including skeletal muscle, liver function, bone mineral density, eye function, insulin sensitivity, immune function, body weight and physical activity level. NMN can also improve the function of retina and increase the secretion of tears. The latest research report published by cell magazine in March 2018 shows that NMN can improve the blood flow and endurance of aging rats, successfully reverse muscle atrophy and vascular death of aging animals, and greatly enhance the vitality of animals. The physical strength of the elderly animals taking NMN was more than 60% of the same age animals. NMN is the first natural organic compound confirmed by rigorous scientific experiments in the world, which can effectively delay and reverse aging and prolong life span. NMN is also a component of natural human body, and no toxic and side effects were found in the experiment. 2、 The world's first long-term oral NMN clinical trial. Japan is the first country to conduct NMN clinical trials. On the basis of completing phase I clinical trials and ensuring safety, the medical department of Keio University started phase II clinical trials in 2017. Clinical trials were carried out in the Graduate School of biomedicine and health, Hiroshima University, and Shinsei pharmaceutical in Japan. The study, which started in 2017 and lasted for one and a half years, aims to study the health effects of long-term NMN use. It is the first clinical confirmation in the world that the expression of longevity protein is increased after oral administration of NMN, and the expression of various types of hormones is also increased. Improvement of nerve conduction circuit (neuralgia, etc.), improvement of immunity, improvement of male and female infertility, enhancement of muscle and bone, improvement of hormone balance (improvement of skin), increase of melatonin (improvement of sleep), Alzheimer's disease caused by brain aging, Parkinson's disease, ischemic encephalopathy and other diseases can be treated and improved or fully recovered 。 In a word, all the symptoms and diseases caused by "aging" have promising effects. 3、 Application prospect -- the role of NMN NMN is a substance called nicotinamide mononucleotide contained in vitamin B3 and exists in all living cells. This is a substance that is naturally produced in the body, but with the growth of age, the production capacity of the body decreases, and eventually the repair function in the body is lost; this is one of the reasons for aging. NMN can stimulate the gradually weakened mitochondria with aging to produce energy, supplement the vitality of mitochondria and provide new kinetic energy for the body. NMN can significantly inhibit the decline of metabolism caused by aging, such as the rise of blood glucose and the decline of immune function. It has a miraculous therapeutic effect on type 2 diabetes. NMN can also effectively prevent aging inducedNMN can also effectively prevent aging induced retinopathy and cognitive decline. The most amazing thing is that it can prolong the life span of experimental animals similar to human beings by up to 31%! The physical strength and explosive power of the elderly animals taking NMN were more than 60% higher than those of the same age animals that did not take NMN, and even exceeded the level of youth The main reason why NMN is favored by the market lies in its relatively perfect laboratory data support. Scientists have confirmed through the laboratory that after ingesting NMN substance, the old mice not only become dark and bright, but also have a physical strength increased by 60%, which is equivalent to prolonging the life span of 31%. After that, scientists found through human clinical trials that the average life span of 9 volunteers who took NMN, the core component of revatrox, for half a year increased by 2.5 years. David Sinclair, a scientist who was selected as "the most influential 100 people in the world" by time magazine, took NMN for two consecutive years After the recent physical examination, it was found that the physiological function grew up to 10 years old. Many of the world's top rich and middle class people have decisively joined the NMN consumer group after learning the experimental results. In 2018, herbal max, the most mature company in NMN market, successfully commercialized NMN (nicotinamide mononucleotide) from Harvard Medical School after nearly three years of scientific research, and sky hope anti-aging brand was put on the market.
